Current Funding Sources:

NIH/NINDS R01-NS090913-01

The motor network in Parkinson's disease: mechanisms of therapy
The goal is to understand the motor network in movement disorders and the mechanism of chronic therapeutic interventions in humans, at very fast time scales, using electrocorticography (ECoG) and EEG. To perform longitudinal studies with ECoG, we ulilize a novel totally implanted bidirectional neural interface (Activa PC+S) attached to permanent cortical and basal ganglia electrodes, in humans undergoing deep bran stimulation therapy.

Defense Advanced Research Projects Agency (DARPA)
Unlearning Neural Systems Dysfunction in Neuropsychiatric disorders

This large multi-PI contract is part of the White House Brain Initiative. The overall goal is to understand brain circuitry underlying depression, anxiety, chronic pain, addiction, and borderline personality disorder, and to develop new therapies for these conditions based on stimulation-induced brain plasticity in combination with cognitive training. The Starr lab part of the grant, “Basal ganglia-frontal circuit function and dysfunction in neuropsychiatric disease” focuses on analysis of prefrontal/basal ganglia circuits mediating nonmotor (psychiatric) fluctuations in Parkinson’s disease.

Closed loop deep brain stimulation for Parkinson's disease

The goal of this project is to perform a small clinical trial of closed loop deep brain stimulation in Parkinson’s disease. Patients are implanted with a second-generation bidirectional neural interface, Activa RC+S, attached to permanent cortical and basal ganglia electrodes. The study will address key questions needed to inform subsequent design of neural interfaces, including the utility of cortical versus basal ganglia signal detection, and selection of frequency bands for optimal control signals.

NIH/NIMH 1R01MH114854-01(Lead Institution: Baylor College of Medicine)
Neuroethics of aDBS Systems Targeting Neuropsychiatric and Movement Disorders

This study aims to identify and empirically examine pressing neuroethics issues related to the use of adaptive deep brain stimulation (aDBS) systems in clinical trials for the treatment of neuropsychiatric and movement disorders.

The Michael J. Fox Foundation for Parkinson's Research
Neurophysiological Signatures of Depression and Impulsivity

The aim of this project is to identify neurophysiological signatures of depression and impulsivity in basal ganglia and cortex, using an investigational device that allows therapeutic stimulation and chronic brain recordings. The device is attached to two permanent electrodes, one placed over the orbitofrontal cortex (OFC)/inferior frontal gyrus (IFG) and the other in the subthalamic nucleus (STN). Brain signals are recorded while modulating the symptom severity with dopaminergic medication. The effect of cortical stimulation on both symptoms severity and brain signals is also being studied.

The Bachman-Strauss Dystonia and Parkinson Foundation


Past Funding Sources:

Dystonia Medical Research Foundation